Sugarman Jeffrey L
Departments of Dermatology and Family Medicine, University of California, San Francisco, CA, USA.
Semin Cutan Med Surg. 2008 Jun;27(2):108-14. doi: 10.1016/j.sder.2008.04.005.
Epidermal barrier function is abnormal in individuals with atopic dermatitis (AD). It is controversial whether primary epidermal barrier abnormalities alone account for the physiological and clinical abnormalities found in those persons with AD or whether the observed barrier dysfunction is a consequence of primary immunologic abnormalities. Recent evidence is strengthening the argument for the former hypothesis. Attention to epidermal barrier care (ie, gentle skin care) has long been an important part of the therapy of AD. Advances in our understanding of the biology of the epidermal barrier and how this relates to the clinical manifestations of this disease has important consequences for new therapeutic approaches in the management of AD.
特应性皮炎（AD）患者的表皮屏障功能异常。原发性表皮屏障异常是否单独导致了AD患者出现的生理和临床异常，或者观察到的屏障功能障碍是否是原发性免疫异常的结果，这一点存在争议。最近的证据正在支持前一种假说。长期以来，关注表皮屏障护理（即温和的皮肤护理）一直是AD治疗的重要组成部分。我们对表皮屏障生物学及其与该疾病临床表现之间关系的理解取得进展，这对AD管理中的新治疗方法具有重要意义。
