饮食与皮肤屏障：饮食干预对皮肤屏障功能的作用
Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function.
作者信息
Parke Milbrey A, Perez-Sanchez Ariadna, Zamil Dina H, Katta Rajani
机构信息
Baylor College of Medicine, Houston, TX, USA.
Internal Medicine, University of Texas Health Science Center at San Antonio, TX, USA.
出版信息
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021132. doi: 10.5826/dpc.1101a132. eCollection 2021 Jan.
Abstract
Multiple research studies have examined the role of specific dietary interventions and their effects on skin barrier function. The skin barrier is one of the body's first lines of protection against environmental insults, and disruption of this natural line of defense can result in xerosis, irritation, chronic dermatitis, and other cutaneous effects. Multiple laboratory, animal, and human studies have demonstrated that certain dietary interventions have the potential to impact skin barrier function. Measurements of skin barrier function include stratum corneum hydration and transepidermal water loss. In this review, we examine this research and provide an overview of the effects of prebiotics, probiotics, fatty acids, and emerging research on other substances.
摘要
多项研究探讨了特定饮食干预措施的作用及其对皮肤屏障功能的影响。皮肤屏障是人体抵御环境侵害的第一道防线之一，破坏这道天然防线会导致皮肤干燥、刺激、慢性皮炎和其他皮肤问题。多项实验室、动物和人体研究表明，某些饮食干预措施有可能影响皮肤屏障功能。皮肤屏障功能的测量包括角质层水合作用和经表皮水分流失。在本综述中，我们审视了这项研究，并概述了益生元、益生菌、脂肪酸以及其他物质的最新研究成果。
相似文献
1
Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function.饮食与皮肤屏障：饮食干预对皮肤屏障功能的作用
Dermatol Pract Concept. 2021 Jan 29;11(1):e2021132. doi: 10.5826/dpc.1101a132. eCollection 2021 Jan.
2
Atopic xerosis: employment of noninvasive biophysical instrumentation for the functional analyses of the mildly abnormal stratum corneum and for the efficacy assessment of skin care products.特应性皮肤干燥症：采用非侵入性生物物理仪器对轻度异常的角质层进行功能分析及对护肤品功效进行评估。
J Cosmet Dermatol. 2006 Jun;5(2):140-9. doi: 10.1111/j.1473-2165.2006.00241.x.
3
Atopic dermatitis and the stratum corneum: part 1: the role of filaggrin in the stratum corneum barrier and atopic skin.特应性皮炎与角质层：第1部分：丝聚合蛋白在角质层屏障及特应性皮肤中的作用
J Clin Aesthet Dermatol. 2013 Oct;6(10):16-22.
4
5
Impairment of skin barrier function is not inherent in atopic dermatitis patients: a prospective study conducted in newborns.皮肤屏障功能受损并非特应性皮炎患者所固有：一项针对新生儿的前瞻性研究。
Pediatr Dermatol. 2006 Mar-Apr;23(2):109-13. doi: 10.1111/j.1525-1470.2006.00191.x.
6
Is the skin barrier abnormal in dogs with atopic dermatitis?特应性皮炎犬的皮肤屏障是否异常？
Vet Immunol Immunopathol. 2011 Nov 15;144(1-2):11-6. doi: 10.1016/j.vetimm.2011.07.014. Epub 2011 Jul 23.
7
Atopic dermatitis and the stratum corneum: part 2: other structural and functional characteristics of the stratum corneum barrier in atopic skin.特应性皮炎与角质层：第2部分：特应性皮肤角质层屏障的其他结构和功能特征
J Clin Aesthet Dermatol. 2013 Nov;6(11):49-54.
8
Functional analyses of the superficial stratum corneum in atopic xerosis.特应性皮肤干燥症中角质层浅层的功能分析。
Arch Dermatol. 1991 Nov;127(11):1689-92.
9
Reevaluation of the non-lesional dry skin in atopic dermatitis by acute barrier disruption: an abnormal permeability barrier homeostasis with defective processing to generate ceramide.通过急性屏障破坏对特应性皮炎中非皮损性干性皮肤的重新评估：一种具有生成神经酰胺加工缺陷的异常渗透屏障稳态。
Arch Dermatol Res. 2014 Jul;306(5):427-40. doi: 10.1007/s00403-013-1430-x. Epub 2013 Nov 23.
10
Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications.皮肤屏障的结构与功能更新：以特应性皮炎为例探讨临床意义
Semin Cutan Med Surg. 2013 Jun;32(2 Suppl 2):S21-4. doi: 10.12788/j.sder.0022.
引用本文的文献
1
Novel Gels for Post-Piercing Care: Evaluating the Efficacy of Pranoprofen Formulations in Reducing Inflammation.用于穿刺后护理的新型凝胶：评估普拉洛芬制剂在减轻炎症方面的疗效。
Gels. 2025 Apr 30;11(5):334. doi: 10.3390/gels11050334.
2
Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy.用于减轻皮肤衰老的营养保健干预措施：作用机制与功效分析
Curr Pharm Des. 2025;31(30):2385-2401. doi: 10.2174/0113816128336661250218080928.
3
Risk factors for cerebrospinal fluid shunt infection in pediatrics: A meta-analysis.小儿脑脊液分流感染的危险因素：一项荟萃分析。
Surg Neurol Int. 2025 Jan 24;16:16. doi: 10.25259/SNI_848_2024. eCollection 2025.
4
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans.益生元部分水解瓜尔胶的饮食干预可改善皮肤粘弹性、角质层水合作用并减少经表皮水分流失：一项针对健康人群的随机、双盲、安慰剂对照临床研究。
J Clin Biochem Nutr. 2025 Jan;76(1):96-115. doi: 10.3164/jcbn.24-69. Epub 2024 Jun 7.
5
Nutritional Dermatology: Optimizing Dietary Choices for Skin Health.营养皮肤病学：优化饮食选择以促进皮肤健康。
Nutrients. 2024 Dec 27;17(1):60. doi: 10.3390/nu17010060.
6
Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources.多不饱和脂肪酸与人类健康：与食物来源的多酚类化合物相关的现代营养平衡之关键。
Foods. 2024 Dec 27;14(1):46. doi: 10.3390/foods14010046.
7
Frequent intake of high fiber and probiotic diets lowers risks associated with atopic dermatitis and house dust mite allergy: a cross-sequential study of young Chinese adults from Singapore and Malaysia.频繁摄入高纤维和益生菌饮食可降低特应性皮炎和屋尘螨过敏的相关风险：来自新加坡和马来西亚的中国年轻人的横断面研究。
Eur J Nutr. 2024 Nov 30;64(1):38. doi: 10.1007/s00394-024-03524-6.
8
Exploring genetic associations between metabolites and atopic dermatitis: insights from bidirectional Mendelian randomization analysis in European population.探索代谢物与特应性皮炎之间的遗传关联：来自欧洲人群双向孟德尔随机化分析的见解
Front Nutr. 2024 Sep 10;11:1451112. doi: 10.3389/fnut.2024.1451112. eCollection 2024.
9
Fibroblasts/three-dimensional scaffolds complexes promote wound healing in rats with skin defects.成纤维细胞/三维支架复合物促进皮肤缺损大鼠的伤口愈合。
Tissue Barriers. 2025 Jan 2;13(1):2334544. doi: 10.1080/21688370.2024.2334544. Epub 2024 Mar 27.
10
Facial Physiological Characteristics and Skin Microbiomes Changes are Associated with Body Mass Index (BMI).面部生理特征和皮肤微生物群变化与体重指数（BMI）相关。
Clin Cosmet Investig Dermatol. 2024 Mar 4;17:513-528. doi: 10.2147/CCID.S447412. eCollection 2024.
本文引用的文献
1
The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions.皮肤与肠道微生物群及其在常见皮肤病中的作用
Microorganisms. 2019 Nov 11;7(11):550. doi: 10.3390/microorganisms7110550.
2
Lysates of a Probiotic, , Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model.益生菌 的 细胞裂解物 可改善 重建人体表皮模型 的 皮肤屏障功能。
Int J Mol Sci. 2019 Sep 2;20(17):4289. doi: 10.3390/ijms20174289.
3
Treatment with Docosahexaenoic Acid Improves Epidermal Keratinocyte Differentiation and Ameliorates Inflammation in Human Keratinocytes and Reconstructed Human Epidermis Models.二十二碳六烯酸治疗可改善表皮角质形成细胞分化，并减轻人角质形成细胞和重建人体表皮模型中的炎症。
Molecules. 2019 Aug 30;24(17):3156. doi: 10.3390/molecules24173156.
4
5
Measurement of transepidermal water loss, stratum corneum hydration and skin surface pH in occupational settings: A review.职业环境中经皮水分丢失、角质层水分和皮肤表面 pH 值的测量：综述。
Skin Res Technol. 2019 Sep;25(5):595-605. doi: 10.1111/srt.12711. Epub 2019 May 20.
6
Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin.罗特氏乳杆菌 DSM 17938-益生菌和裂解物对人体皮肤影响的比较研究。
Exp Dermatol. 2019 Jul;28(7):822-828. doi: 10.1111/exd.13950. Epub 2019 May 15.
7
Randomized Controlled Pilot Study of Dietary Supplementation with Turmeric or Herbal Combination Tablets on Skin Barrier Function in Healthy Subjects.姜黄或草药组合片膳食补充剂对健康受试者皮肤屏障功能影响的随机对照初步研究。
J Med Food. 2018 Dec;21(12):1260-1265. doi: 10.1089/jmf.2018.0015. Epub 2018 Nov 20.
8
Impact of water exposure on skin barrier permeability and ultrastructure.水暴露对皮肤屏障通透性和超微结构的影响。
Contact Dermatitis. 2019 Apr;80(4):228-233. doi: 10.1111/cod.13174. Epub 2018 Dec 14.
9
Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis.用于特应性皮炎管理的保湿剂与当前及下一代屏障修复疗法对比
Skin Pharmacol Physiol. 2019;32(1):1-7. doi: 10.1159/000493641. Epub 2018 Oct 18.
10
Complementary and alternative medicine for treatment of atopic eczema in children under 14 years old: a systematic review and meta-analysis of randomized controlled trials.补充和替代医学治疗 14 岁以下儿童特应性皮炎：随机对照试验的系统评价和荟萃分析。
BMC Complement Altern Med. 2018 Sep 26;18(1):260. doi: 10.1186/s12906-018-2306-6.
Zotero 插件