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[内脏利什曼病继发噬血细胞综合征]

[Hemophagocytic syndrome secondary to visceral leishmaniasis].

作者信息

Sotoca Fernández J V, García Villaescusa L, Lillo Lillo M, García Mialdea O, Carrascosa Romero M C, Tébar Gil R

机构信息

Servicio de Pediatría, Hospital General Universitario de Albacete, Albacete, Spain.

出版信息

An Pediatr (Barc). 2008 Jul;69(1):46-8. doi: 10.1157/13124218.

Abstract

Haemophagocytic syndrome is a disease diagnosed according to clinical and analytical criteria, related to many infectious diseases. It is exceptionally described in patients infected with Leishmania. Visceral leishmaniasis is an uncommon disease in our country except in some areas where it is endemic. Its diagnosis is sometimes difficult and the use of other methods currently available is needed. Haemophagocytic syndrome treatment is based on established chemotherapy protocols, but when it is secondary to Visceral Leishmaniasis, it may be an exception, since the abnormalities can be resolved by treatment of the infection itself. This treatment has improved recently as Liposomal Amphotericin B has replaced classic antimonials, being more beneficial due to less adverse effects and a shorter treatment time.

摘要

噬血细胞综合征是一种根据临床和分析标准诊断的疾病,与多种传染病相关。在感染利什曼原虫的患者中对其进行描述的情况极为罕见。内脏利什曼病在我国是一种罕见疾病,某些流行地区除外。其诊断有时较为困难,需要使用目前可用的其他方法。噬血细胞综合征的治疗基于既定的化疗方案,但当它继发于内脏利什曼病时可能是个例外,因为通过治疗感染本身异常情况可能会得到解决。随着脂质体两性霉素B取代了传统的锑剂,这种治疗方法最近有所改进,由于副作用更少、治疗时间更短而更具优势。

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