Harnod Tomor, Yang Cheryl C H, Hsin Yue-Loong, Wang Pen-Jung, Shieh Kun-Ruey, Kuo Terry B J
Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Seizure. 2009 Jan;18(1):21-5. doi: 10.1016/j.seizure.2008.05.013. Epub 2008 Jul 11.
To identify autonomic dysregulation in frontal lobe epilepsy (FLE).
We studied 14 male and 11 female subjects with FLE and an equal number of matched healthy control subjects. Lead I electrocardiograms were obtained for 5 min in the interictal state during daytime. Frequency-domain analysis of heart rate variability was performed and the data subsequently converted to heart rate interval and high frequency (HF; 0.15-0.45 Hz) power which representing vagal or parasympathetic regulation, as well as low frequency (LF; 0.04-0.15 Hz) power and LF/(HF+LF) expressed in normalized units (LF%) (considered to mirror sympathetic regulation). Differences in data between groups were compared using t-test.
The epilepsy group had a lower mean heart rate interval and a lower high frequency power.
Patients with FLE have interictally faster heart rates, attributed to lower parasympathetic drive, which may contribute to the higher incidence of sudden death that is seen in this group of patients. This suggests that the mechanism of decreased HRV in patients with FLE is probably different from that in patients with temporal lobe epilepsy.
识别额叶癫痫（FLE）中的自主神经调节异常。
我们研究了14名男性和11名女性FLE患者以及数量相等的匹配健康对照者。在白天发作间期状态下记录5分钟的I导联心电图。进行心率变异性的频域分析，随后将数据转换为心率间期以及代表迷走神经或副交感神经调节的高频（HF；0.15 - 0.45Hz）功率，以及低频（LF；0.04 - 0.15Hz）功率和以标准化单位表示的LF/(HF + LF)（LF%）（被认为反映交感神经调节）。使用t检验比较两组数据的差异。
癫痫组的平均心率间期和高频功率较低。
FLE患者在发作间期心率较快，这归因于较低的副交感神经驱动力，这可能导致该组患者中较高的猝死发生率。这表明FLE患者心率变异性降低的机制可能与颞叶癫痫患者不同。
