Clarke P
Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, MI 48106-1248, USA.
J Epidemiol Community Health. 2008 Aug;62(8):752-8. doi: 10.1136/jech.2007.060798.
The use of multilevel modelling with data from population-based surveys is often limited by the small number of cases per level-2 unit, prompting many researchers to use single-level techniques such as ordinary least squares regression.
Monte Carlo simulations are used to investigate the effects of data sparseness on the validity of parameter estimates in two-level versus single-level models.
Both linear and non-linear hierarchical models are simulated in order to examine potential differences in the effects of small group size across continuous and discrete outcomes. Results are then compared with those obtained using disaggregated techniques (ordinary least squares and logistic regression).
At the extremes of data sparseness (two observations per group), the group level variance components are overestimated in the two-level models. But with an average of only five observations per group, valid and reliable estimates of all parameters can be obtained when using a two-level model with either a continuous or a discrete outcome. In contrast, researchers run the risk of Type I error (standard errors biased downwards) when using single-level models even when there are as few as two observations per group on average. Bias is magnified when modelling discrete outcomes.
Multilevel models can be reliably estimated with an average of only five observations per group. Disaggregated techniques carry an increased risk of Type I error, even in situations where there is only limited clustering in the data.
基于人群调查数据使用多水平模型常常受到二级单位中病例数较少的限制,这促使许多研究人员使用诸如普通最小二乘法回归等单水平技术。
采用蒙特卡洛模拟来研究数据稀疏性对二级模型与单水平模型中参数估计有效性的影响。
对线性和非线性分层模型进行模拟,以检验在连续和离散结果中小组规模较小所产生影响的潜在差异。然后将结果与使用分解技术(普通最小二乘法和逻辑回归)获得的结果进行比较。
在数据稀疏的极端情况下(每组两个观测值),二级模型中的组水平方差成分被高估。但每组平均仅有五个观测值时,使用具有连续或离散结果的二级模型可以获得所有参数的有效且可靠的估计值。相比之下,即使平均每组仅有两个观测值,研究人员在使用单水平模型时也存在I型错误的风险(标准误差向下偏差)。在对离散结果进行建模时偏差会放大。
每组平均仅有五个观测值时,多水平模型也能得到可靠估计。即使在数据中聚类有限的情况下,分解技术也会增加I型错误的风险。