Rauf Abdul, Gangal Saloni
Department of Chemistry, Aligarh Muslim University, Aligarh, India.
J Oleo Sci. 2008;57(8):453-7. doi: 10.5650/jos.57.453.
N-acyl-1H-1,2,3-benzotriazoles were prepared in good yields by the reaction of benzotriazole and thionyl chloride with olefinic fatty acids under mild reaction conditions. The new compounds 1-(undec-10-enoyl)-1H-1,2,3-benzotriazole (5a),1-[(Z)-octadec-9-enoyl]-1H-1,2,3-benzotriazole (5b), 1-[(9Z,12R)-12-hydroxyoctadec-9-enoyl]-1H-1,2,3-benzotriazole (5c), 1-[(9R,12Z)-9-hydroxyoctadec-12-enoyl]-1H-1,2,3-benzotriazole (5d) formed were characterized on the basis of elemental analysis and spectral data. All the newly synthesized compounds (5a-5d) were screened for their antimicrobial activity and showed good antifungal activity.
在温和的反应条件下，通过苯并三唑、亚硫酰氯与烯属脂肪酸反应，以良好的产率制备了N-酰基-1H-1,2,3-苯并三唑。基于元素分析和光谱数据对新形成的化合物1-(十一碳-10-烯酰基)-1H-1,2,3-苯并三唑(5a)、1-[(Z)-十八碳-9-烯酰基]-1H-1,2,3-苯并三唑(5b)、1-[(9Z,12R)-12-羟基十八碳-9-烯酰基]-1H-1,2,3-苯并三唑(5c)、1-[(9R,12Z)-9-羟基十八碳-12-烯酰基]-1H-1,2,3-苯并三唑(5d)进行了表征。对所有新合成的化合物(5a - 5d)进行了抗菌活性筛选，结果显示它们具有良好的抗真菌活性。
