Gamboa David G, Sugarman Jeffrey L
Children's Hospital & Research Center Oakland, Oakland, USA.
Curr Opin Pediatr. 2008 Aug;20(4):413-8. doi: 10.1097/MOP.0b013e328306eba1.
This review highlights recent advances in our current understanding of several autoimmune disorders that affect adolescents. Systemic lupus erythematosus, juvenile dermatomyositis, and juvenile localized scleroderma stand out among the connective tissue diseases for their multiorgan involvement, significant potential morbidity, and the challenges of chronic treatment.
A better understanding of the pathogenesis of these diseases and new insights into the relationship between the immune dysregulation and clinical features has allowed for the development of novel therapies that are more efficacious and targeted than traditional therapies.
This article provides an update of the recent literature, highlighting advances that the general pediatrician should know in the care of adolescents with these diseases.
本综述重点介绍了我们目前对几种影响青少年的自身免疫性疾病的最新认识进展。系统性红斑狼疮、青少年皮肌炎和青少年局限性硬皮病在结缔组织疾病中尤为突出，因为它们会累及多个器官，具有显著的潜在发病率，以及慢性治疗带来的挑战。
对这些疾病发病机制的更好理解以及对免疫失调与临床特征之间关系的新见解，使得新型疗法得以开发，这些疗法比传统疗法更有效且更具针对性。
本文提供了近期文献的更新内容，重点介绍了普通儿科医生在照顾患有这些疾病的青少年时应了解的进展。
