Wanhainen A, Rasmussen M, Björck L, Björck M
Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University Hospital, Uppsala, Sweden.
Vasa. 2008 May;37(2):143-9. doi: 10.1024/0301-1526.37.2.143.
In a population-based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed.
Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, SclB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical).
Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with controls (0.25 vs 0.17, p = 0.021). A similar trend was observed in current GRAB antibody levels (0.23 vs 0.17, p = 0.072). GRAB-antibody levels at age 60 years retained the association with AAA in a logistic regression model after adjustment for a history of atherosclerosis (OR 20.2, p = 0.022), current smoking (OR 21.4, p = 0.025) and family history of AAA (OR 12.9, p = 0.053). Current and historical antibody levels against SclA and SclB in AAA patients were similar to those in controls.
The results indicate that the immune response against S. pyogenes protein GRAB may be involved in the pathogenesis of AAA.
在一项基于人群的病例对照研究中，分析了抗化脓性链球菌抗原抗体与腹主动脉瘤（AAA）发生之间的关联。
将42例经筛查发现患有AAA的患者与100例年龄和性别匹配、主动脉正常的对照者进行比较。在筛查时采集的血浆样本（当前样本）以及12年前对同一人群进行的一项研究中采集的样本（历史样本）中，分析了针对化脓性链球菌三种最近鉴定出的细胞壁附着蛋白（SclA、SclB和GRAB）的抗体。
与对照者相比，AAA患者中针对化脓性链球菌抗原GRAB的历史抗体水平显著更高（0.25对0.17，p = 0.021）。在当前GRAB抗体水平上也观察到类似趋势（0.23对0.17，p = 0.072）。在对动脉粥样硬化病史、当前吸烟情况和AAA家族史进行调整后，60岁时的GRAB抗体水平在逻辑回归模型中仍与AAA相关（比值比20.2，p = 0.022），当前吸烟（比值比21.4，p = 0.025）以及AAA家族史（比值比12.9，p = 0.053）。AAA患者中针对SclA和SclB的当前和历史抗体水平与对照者相似。
结果表明，针对化脓性链球菌蛋白GRAB的免疫反应可能参与了AAA的发病机制。
