Lindblad B, Börner G, Gottsäter A
Department of Vascular Diseases Malmö-Lund, Malmö University Hospital, Lund University, Malmö, Sweden.
Eur J Vasc Endovasc Surg. 2005 Oct;30(4):346-52. doi: 10.1016/j.ejvs.2005.04.021.
To investigate whether any variables in a health-screened population study were associated with later development of large abdominal aortic aneurysms (AAA).
Malmö, Southern Sweden.
Within the Malmö Preventive Study 22,444 men and 10,982 women were investigated between 1974 and 1991. The mean age at the health screening was 43.7 years.
After a median follow-up of 21 years, 126 men and six women (p<0.001) had large AAA that were symptomatic or evaluated for operation (5 cm diameter or more) or had autopsy-verified ruptured AAA. The male group (mean age 47 years) was, because of difference in age (p<0.001) also compared with an age-matched control group. The male patients with AAA showed increased diastolic blood pressure (p<0.007) at the health screening. Smoking predicted the development of AAA (p<0.0001). No difference in forced vital capacity or BMI was seen. Those who were physically inactive (e.g. not walking or cycling to work) had an increased risk of developing AAA (p<0.001). Among the laboratory markers measured, the erythrocyte sedimentation rate did not differ (7.1+/-5.9 vs. 6.4+/-5.7), but cholesterol (6.3+/-1.12 vs. 5.8+/-1.0) (p<0.0001) and triglycerides (1.9+/-0.12 vs. 1.5+/-0.07) (p<0.001) were significantly elevated in these individuals who subsequently developing AAA. The inflammatory proteins alfa-1-antitrypsin, ceruloplasmin, orosmucoid, fibrinogen, and haptoglobulin were increased (p<0.001).
Male gender, smoking, physical inactivity and cholesterol are significant factors associated with the development of AAA.
调查健康筛查人群研究中的任何变量是否与后来大型腹主动脉瘤（AAA）的发生有关。
瑞典南部马尔默。
在马尔默预防研究中，于1974年至1991年间对22444名男性和10982名女性进行了调查。健康筛查时的平均年龄为43.7岁。
经过21年的中位随访，126名男性和6名女性（p<0.001）患有有症状的大型AAA或接受了手术评估（直径5厘米或更大），或经尸检证实为AAA破裂。由于年龄差异（p<0.001），男性组（平均年龄47岁）也与年龄匹配的对照组进行了比较。患有AAA的男性患者在健康筛查时舒张压升高（p<0.007）。吸烟可预测AAA的发生（p<0.0001）。用力肺活量或体重指数未见差异。身体不活动者（如不步行或骑自行车上班）发生AAA的风险增加（p<0.001）。在所测量的实验室指标中，红细胞沉降率无差异（7.1±5.9对6.4±5.7），但随后发生AAA的个体中胆固醇（6.3±1.12对5.8±1.0）（p<0.0001）和甘油三酯（1.9±0.12对1.5±0.07）（p<0.001）显著升高。炎症蛋白α-1-抗胰蛋白酶、铜蓝蛋白、类粘蛋白、纤维蛋白原和触珠蛋白升高（p<0.001）。
男性、吸烟、身体不活动和胆固醇是与AAA发生相关的重要因素。
