Chiba S
Jpn Heart J. 1977 May;18(3):398-405. doi: 10.1536/ihj.18.398.
Using isolated, blood-perfused atrium preparation of the dogs, the effect of stretch on sinus rate was studied in 11 preparations. Stretching usually produced sinus acceleration in all 11 spontaneously beating atria. Within a range of 0--30 Gm, greater degrees of stretch produced greater degrees of sinus acceleration. During maintained stretch sinus rate slightly reduced but not to the control rate. On release from stretch sinus rate immediately returned to the control rate, and there was occasionally a slowing to rates lower than control in verapamil treated preparations. Atropine, adrenergic beta-receptor blocking agents, propranolol and carteolol, verapamil, and tetrodotoxin did not greatly modify responses to stretching.
利用犬的离体、血液灌流心房标本，在11个标本中研究了牵张对窦性心率的影响。在所有11个自主搏动的心房中，牵张通常会引起窦性加速。在0至30克的范围内，牵张程度越大，窦性加速程度越大。在持续牵张期间，窦性心率略有下降，但未降至对照心率。牵张解除后，窦性心率立即恢复到对照心率，在维拉帕米处理的标本中，偶尔会减慢至低于对照的心率。阿托品、肾上腺素能β受体阻断剂、普萘洛尔和卡替洛尔、维拉帕米和河豚毒素对牵张反应的影响不大。
