Korochkin I M, Verbitskaia I A, Okuneva I N, Krupnik V E, Polevaia O Iu
Sov Med. 1991(1):25-7.
The important role played by prostaglandins in the pathogenesis of coronary disease and essential hypertension is well known. The authors have attempted to reveal a relationship between blood levels of natural autoantibodies to PGF2 alpha and PGE2 and specific features of coronary disease and essential hypertension course and complications. A total of 87 subjects were examined, 23 of these--normal controls, 25 patients with myocardial infarction, 22 with angina pectoris, and 17 with essential hypertension. Solid-phase enzyme immunoassay was employed to detect anti-PGF2 alpha and anti-PGE2 antibodies. These antibodies were found in normal subjects, coronary patients and hypertensives. Blood levels of these antibodies correlated with some complications of coronary disease and essential hypertension. These results permit a hypothesis that the pathogenetic physiologic role of the detected natural antibodies to prostaglandins consists in their defense homeostatic function.
前列腺素在冠心病和原发性高血压发病机制中所起的重要作用是众所周知的。作者试图揭示针对PGF2α和PGE2的天然自身抗体的血液水平与冠心病和原发性高血压病程及并发症的特定特征之间的关系。总共检查了87名受试者，其中23名是正常对照，25名心肌梗死患者，22名心绞痛患者和17名原发性高血压患者。采用固相酶免疫测定法检测抗PGF2α和抗PGE2抗体。在正常受试者、冠心病患者和高血压患者中均发现了这些抗体。这些抗体的血液水平与冠心病和原发性高血压的一些并发症相关。这些结果提出了一个假设，即所检测到的针对前列腺素的天然抗体的致病生理作用在于其防御稳态功能。
