Aho K
Med Biol. 1980 Feb;58(1):8-13.
The prevalence of many autoantibodies increases with age. There is much circumstantial evidence from cross-sectional studies and a limited amount of more straightforward evidence from longitudinal studies suggesting that these autoantibodies act as a risk factor for death. The effector mechanisms as well as the relationship to established risk factors are unknown and little information is available on the genetics of autoimmune seroreactions as distinct from autoimmune diseases.
许多自身抗体的患病率会随着年龄的增长而升高。横断面研究提供了大量间接证据，纵向研究也提供了少量更为直接的证据，这些证据表明这些自身抗体是导致死亡的一个风险因素。其效应机制以及与既定风险因素之间的关系尚不清楚，而且与自身免疫性疾病不同，关于自身免疫性血清反应遗传学的信息也很少。
