Sello Jason K, Buttner Mark J
Department of Molecular Microbiology, John Innes Centre, Norwich, UK.
FEMS Microbiol Lett. 2008 Sep;286(1):60-5. doi: 10.1111/j.1574-6968.2008.01260.x.
Transcriptional analysis of the gene in Streptomyces coelicolor encoding oligoribonuclease indicates that it is not transcriptionally or translationally coupled to adpA, a key bldA target for morphological differentiation. Interestingly, construction and phenotypic analysis of an S. coelicolor oligoribonuclease null mutant revealed a conditional defect in morphological differentiation that is reminiscent of bldA and other known developmental mutants.
对天蓝色链霉菌中编码寡核糖核酸酶的基因进行转录分析表明,它在转录或翻译上与adpA没有偶联,adpA是形态分化的关键bldA靶标。有趣的是,天蓝色链霉菌寡核糖核酸酶缺失突变体的构建和表型分析揭示了形态分化中的条件性缺陷,这让人联想到bldA和其他已知的发育突变体。