Jones George H
Department of Biology, College of Arts and Sciences, Emory University, Atlanta, GA, United States.
Front Microbiol. 2023 Apr 11;14:1096228. doi: 10.3389/fmicb.2023.1096228. eCollection 2023.
are soil dwelling bacteria that are notable for their ability to sporulate and to produce antibiotics and other secondary metabolites. Antibiotic biosynthesis is controlled by a variety of complex regulatory networks, involving activators, repressors, signaling molecules and other regulatory elements. One group of enzymes that affects antibiotic synthesis in is the ribonucleases. In this review, the function of five ribonucleases, RNase E, RNase J, polynucleotide phosphorylase, RNase III and oligoribonuclease, and their impact on antibiotic production will be discussed. Mechanisms for the effects of RNase action on antibiotic synthesis are proposed.
是一类土壤栖息细菌，以其形成芽孢以及产生抗生素和其他次生代谢产物的能力而闻名。抗生素生物合成受多种复杂调控网络的控制，涉及激活剂、阻遏物、信号分子和其他调控元件。一类影响抗生素合成的酶是核糖核酸酶。在本综述中，将讨论核糖核酸酶E、核糖核酸酶J、多核苷酸磷酸化酶、核糖核酸酶III和寡核糖核酸酶这五种核糖核酸酶的功能及其对抗生素产生的影响。还提出了核糖核酸酶作用对抗生素合成影响的机制。
