Seitz H J, Müller M J, Nordmeyer P, Krone W, Tarnowski W
Endocrinology. 1976 Nov;99(5):1313-8. doi: 10.1210/endo-99-5-1313.
The concentration of insulin and glucagon in peripheral blood and the concentration of cAMP in liver was followed in rats throughout a 48 hour starvation period and up to 6 hours afer refeeding glucose or casein. By so changing the insulin/glucagon molar ratio from minimum to maximum values, simultaneous inverse changes in the concentration of hepatic cAMP could be induced. The study, thus, suggests that during a starvation-refeeding cycle the level of cAMP in the liver is regulated predominantly by the insulin/glucagon ratio in the blood. Possible criticisms of this conclusion are discussed.
在整个48小时饥饿期及重新喂食葡萄糖或酪蛋白后长达6小时的时间里，对大鼠外周血中胰岛素和胰高血糖素的浓度以及肝脏中cAMP的浓度进行了跟踪监测。通过如此将胰岛素/胰高血糖素摩尔比从最小值改变为最大值，可诱导肝脏中cAMP浓度同时发生相反变化。因此，该研究表明，在饥饿-再喂养周期中，肝脏中cAMP的水平主要由血液中的胰岛素/胰高血糖素比值调节。讨论了对这一结论可能的批评意见。
