他汀类药物与心力衰竭患者心房颤动的预防。

Statins and prevention of atrial fibrillation in patients with heart failure.

出版信息

Int J Cardiol. 2009 Jul 10;135(3):e83-4. doi: 10.1016/j.ijcard.2008.04.042. Epub 2008 Jul 14.

DOI:10.1016/j.ijcard.2008.04.042

Abstract

Statins are highly effective and widely used lipid-lowering agents in clinical practice, that also display a number of pleiotropic properties beyond cholesterol lowering. Several trials have demonstrated that they reduce cardiovascular morbidity and mortality in both primary and secondary prevention. Atrial fibrillation (AF) and heart failure (HF) represent 2 world-wide epidemics. Recent evidence suggests that statins may have beneficial effects on cardiovascular outcomes in patients with HF, and specifically in the prevention of AF. The anti-arrhythmic mechanisms of statins regarding AF prevention in HF patients are not fully understood but are possibly related to their pleiotropic effects including anti-inflammatory, antioxidant, atrial remodeling attenuation, ion channel stabilization, and autonomic nervous system regulation.

摘要

他汀类药物是临床实践中高效且广泛应用的降脂药物，除了降低胆固醇外，还具有多种多效性。多项试验表明，它们可降低一级和二级预防人群的心血管发病率和死亡率。心房颤动（AF）和心力衰竭（HF）是全球范围内的 2 大流行病。最近的证据表明，他汀类药物可能对 HF 患者的心血管结局产生有益影响，特别是在预防 AF 方面。关于他汀类药物预防 HF 患者 AF 的抗心律失常机制尚不完全清楚，但可能与它们的多效性作用有关，包括抗炎、抗氧化、心房重构衰减、离子通道稳定和自主神经系统调节。