Richards Justin J, Reed Catherine S, Melander Christian
North Carolina State University, Department of Chemistry, 2620 Yarborough Drive, Raleigh, NC 27695-8204, USA.
Bioorg Med Chem Lett. 2008 Aug 1;18(15):4325-7. doi: 10.1016/j.bmcl.2008.06.089. Epub 2008 Jun 28.
Bacteria of the genus Acinetobacter spp. are rapidly emerging as problematic pathogens in healthcare settings. This is exacerbated by the bacteria's ability to form robust biofilms. Marine natural products incorporating a 2-aminoimidazole (2-AI) motif, namely from the oroidin class of marine alkaloids, have served as a unique scaffold for developing molecules that have the ability to inhibit and disperse bacterial biofilms. Herein we present the anti-biofilm activity of a small library of second generation oroidin analogues against the bacterium Acinetobacter baumannii.
不动杆菌属细菌正迅速成为医疗机构中引发问题的病原体。细菌形成坚固生物膜的能力加剧了这一问题。含有2-氨基咪唑（2-AI）基序的海洋天然产物，即来自海洋生物碱类的oroidin类，已成为开发具有抑制和分散细菌生物膜能力的分子的独特支架。在此，我们展示了第二代oroidin类似物的一个小型文库对鲍曼不动杆菌的抗生物膜活性。
