Melander Roberta J, Liu Hong-Bing, Stephens Matthew D, Bewley Carole A, Melander Christian
Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, United States.
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5863-5866. doi: 10.1016/j.bmcl.2016.11.018. Epub 2016 Nov 9.
Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance.
迫切需要不依赖于开发杀菌化合物的新方法来对抗多重耐药（MDR）细菌。通过证明吡咯 - 咪唑生物碱可抑制生物膜形成并抑制抗生素耐药性，表明了海洋次生代谢产物作为非传统抗菌剂来源的潜力。
