Loftus I, Thompson M
St George's Vascular Institute, St George's University of London, Blackshaw Road, London SW17 0QT, United Kingdom.
Eur J Vasc Endovasc Surg. 2008 Nov;36(5):507-16. doi: 10.1016/j.ejvs.2008.06.002. Epub 2008 Jul 14.
Our understanding of the events that occur within atherosclerotic plaques has improved dramatically over the last 2 decades, particularly with regard to the role of plaque destabilisation and the onset of clinical ischaemic syndromes. Many potential targets have been identified for therapeutic intervention aimed at disease prevention, plaque stabilisation and regression. Furthermore, many potential biomarkers of vascular disease have generated interest in terms of monitoring disease activity and the effect of therapeutic agents. However, despite much scientific promise with in vitro cell and animal models, there has been much less success in modulation of these processes in clinical practice. This review will highlight the local and systemic factors associated with disease progression and acute plaque destabilisation, the current role of therapeutic agents and the potential for targeted plaque modification.
在过去20年里，我们对动脉粥样硬化斑块内发生的事件的理解有了显著提高，特别是在斑块不稳定的作用和临床缺血综合征的发病方面。针对疾病预防、斑块稳定和消退的治疗干预，已经确定了许多潜在靶点。此外，许多潜在的血管疾病生物标志物在监测疾病活动和治疗药物的效果方面引起了人们的兴趣。然而，尽管体外细胞和动物模型有很大的科学前景，但在临床实践中对这些过程的调节取得的成功要少得多。本综述将重点介绍与疾病进展和急性斑块不稳定相关的局部和全身因素、治疗药物的当前作用以及靶向斑块修饰的潜力。
