Torac E, Gaman L, Atanasiu V
Biochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
J Med Life. 2014 Oct-Dec;7(4):481-7.
Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors could be considered as a proatherogenic factor - RCAN1. RCAN1 is a regulator of calcineurin, both of them being calcium dependent proteins. Recent studies have shown that RCAN1 has an important role in heart valve development. In the same time researchers found that, the atherosclerotic plaques have an up-regulated RCAN1 gene expression. In the near future, it is desirable to elucidate the RCAN1 function and classify it as a possible biochemical marker to diagnose infancy atherosclerosis.
动脉粥样硬化是心血管疾病的主要病因之一，是一个涉及多种因素的复杂过程。除血管脂质积累外，炎症因子可被视为一种促动脉粥样硬化因子——RCAN1。RCAN1是钙调神经磷酸酶的调节剂，二者均为钙依赖性蛋白。最近的研究表明，RCAN1在心脏瓣膜发育中起重要作用。同时，研究人员发现，动脉粥样硬化斑块中RCAN1基因表达上调。在不久的将来，希望能够阐明RCAN1的功能，并将其归类为诊断婴儿动脉粥样硬化的一种可能的生化标志物。
