Minton Timothy J
Department of Otolaryngology and Communication Sciences, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA.
Curr Opin Otolaryngol Head Neck Surg. 2008 Aug;16(4):376-80. doi: 10.1097/MOO.0b013e3283079cac.
The incidence of cutaneous malignancies continues to rise and it is likely that the majority of skin cancers referred to otolaryngologists will have characteristics that necessitate a more complex and aggressive approach. Mohs micrographic surgery is a tissue-sparing technique that allows for excision of cancers under complete microscopic control and thus boasts high cure rates. This paper reviews the Mohs technique and discusses the current indications for Mohs surgery in the head and neck.
For high-risk basal cell and squamous cell carcinomas, studies continue to report superior cure rates with Mohs surgery compared with non-Mohs modalities such as standard surgical excision. Despite several supporting studies, Mohs surgery for melanoma continues to be controversial in the literature, as histological identification of melanoma with frozen sections remains challenging despite advances. Other means of margin control remain popular among non-Mohs surgeons, including frozen section analysis and, more recently, photodynamic delineation.
For cutaneous malignancies of the head and neck, Mohs surgery offers the distinct advantages of complete microscopic margin control coupled with tissue conservation and thus boasts of high cure rates. It is important for otolaryngologists to understand the technique and current indications for Mohs surgery.
皮肤恶性肿瘤的发病率持续上升,转诊至耳鼻喉科医生处的大多数皮肤癌可能具有需要更复杂和积极治疗方法的特征。莫氏显微外科手术是一种保留组织的技术,能够在完全显微镜控制下切除癌症,因此治愈率很高。本文回顾了莫氏技术,并讨论了目前头颈部莫氏手术的适应证。
对于高危基底细胞癌和鳞状细胞癌,研究继续报告与标准手术切除等非莫氏手术方式相比,莫氏手术的治愈率更高。尽管有多项支持性研究,但莫氏手术治疗黑色素瘤在文献中仍存在争议,因为尽管取得了进展,但通过冰冻切片对黑色素瘤进行组织学鉴定仍然具有挑战性。其他切缘控制方法在非莫氏外科医生中仍然很受欢迎,包括冰冻切片分析以及最近的光动力描绘。
对于头颈部皮肤恶性肿瘤,莫氏手术具有完全显微镜下切缘控制以及组织保留的显著优势,因此治愈率很高。耳鼻喉科医生了解莫氏手术的技术和当前适应证非常重要。