Franko Debra L, Dorer David J, Keel Pamela K, Jackson Safia, Manzo Mary Pat, Herzog David B
Department of Psychiatry, Harris Center for Eating Disorders, Massachusetts General Hospital, Boston, MA 02114, USA.
J Nerv Ment Dis. 2008 Jul;196(7):556-61. doi: 10.1097/NMD.0b013e31817d0153.
To examine the relationship between drug abuse and eating disorders in a longitudinal sample. In a prospective study, women diagnosed with either DSM-IV anorexia nervosa (n = 136) or bulimia nervosa (n = 110) were interviewed and assessed for research diagnostic criteria drug use disorder (DUD) every 6-12 months over 8.6 years. Contrary to expectation, DUD did not influence recovery from either eating disorder. Multivariate analyses indicated that alcohol use and suicide attempts over the course of the study, as well as hospitalization for an affective disorder before the study, predicted DUD in anorexia nervosa. For bulimia nervosa, multivariate predictors included the severity of alcohol use and the severity of bulimic symptoms over the course of the study, and a hospitalization before study entry for a nonaffective disorder. Drug abuse in women with eating disorders is an area of clinical concern and should be monitored routinely.
在一个纵向样本中研究药物滥用与饮食失调之间的关系。在一项前瞻性研究中，对被诊断为DSM-IV神经性厌食症（n = 136）或神经性贪食症（n = 110）的女性进行了访谈，并在8.6年的时间里每6 - 12个月评估一次研究诊断标准药物使用障碍（DUD）。与预期相反，DUD并未影响任何一种饮食失调的康复。多变量分析表明，在研究过程中的酒精使用和自杀企图，以及研究前因情感障碍住院，可预测神经性厌食症中的DUD。对于神经性贪食症，多变量预测因素包括研究过程中酒精使用的严重程度和贪食症状的严重程度，以及研究入组前因非情感障碍住院。饮食失调女性中的药物滥用是一个临床关注的领域，应进行常规监测。
