Gündüz Kaan, Pulido Jose S, Pulido Jose E, Link Thomas
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
Retina. 2008 Oct;28(9):1257-64. doi: 10.1097/IAE.0b013e31817d5cdc.
To correlate fundus autofluorescence (FAF) patterns with fluorescein/indocyanine green angiographic (FA/ICGA) features in choroidal melanocytic lesions.
Retrospective chart review of 30 consecutive patients with choroidal nevi and melanoma who underwent FAF photography and FA/ICGA. The FAF pattern was classified as patchy or diffuse. The FA images were evaluated at the arterial, early venous, late venous, midphase, and late phases. The ICGA images were evaluated at the early and midlate phase. The fluorescence within the tumor was classified as hyperfluorescent, pinpoint hyperfluorescent, isofluorescent, or hypofluorescent with respect to the surrounding retina or choroid. Statistical analysis was performed using two sample t test for continuous data. For categorical or ordinal data, Pearson chi-square or Fisher's exact test was used depending on the sample size being studied.
Nineteen of 30 tumors (63.3%) were choroidal melanoma and 11 (36.7%) were choroidal nevus. Thirteen choroidal melanomas had a diffuse FAF pattern. Six choroidal melanomas and 11 choroidal nevi had a patchy FAF pattern. The diffuse FAF pattern was significantly associated with the clinical diagnosis of choroidal melanoma versus choroidal nevus (P = 0.00001), increased tumor thickness (P = 0.00001), and increased tumor base diameter (P = 0.001), partially pigmented or amelanotic versus pigmented lesion color (P = 0.006), early venous hyperfluorescence on FA (P = 0.015), and late hyperfluorescence on FA (P = 0.018).
Diffuse FAF is more often associated with larger choroidal melanomas as well as early venous and late hyperfluorescence on FA angiography.
将脉络膜黑素细胞性病变的眼底自发荧光（FAF）模式与荧光素/吲哚菁绿血管造影（FA/ICGA）特征相关联。
对30例连续的脉络膜痣和黑色素瘤患者进行回顾性病历审查，这些患者均接受了FAF摄影及FA/ICGA检查。FAF模式分为斑片状或弥漫性。在动脉期、早期静脉期、晚期静脉期、中期和晚期评估FA图像。在早期和中晚期评估ICGA图像。相对于周围视网膜或脉络膜，肿瘤内的荧光分为高荧光、点状高荧光、等荧光或低荧光。对于连续数据，使用两样本t检验进行统计分析。对于分类或有序数据，根据所研究的样本量使用Pearson卡方检验或Fisher精确检验。
30个肿瘤中，19个（63.3%）为脉络膜黑色素瘤，11个（36.7%）为脉络膜痣。13例脉络膜黑色素瘤具有弥漫性FAF模式。6例脉络膜黑色素瘤和11例脉络膜痣具有斑片状FAF模式。弥漫性FAF模式与脉络膜黑色素瘤与脉络膜痣的临床诊断显著相关（P = 0.00001），肿瘤厚度增加（P = 0.00001），肿瘤基底直径增加（P = 0.001），部分色素沉着或无色素与色素沉着病变颜色（P = 0.006），FA上的早期静脉高荧光（P = 0.015），以及FA上的晚期高荧光（P = 0.018）。
弥漫性FAF更常与较大的脉络膜黑色素瘤以及FA血管造影上的早期静脉和晚期高荧光相关。
