Bindewald-Wittich Almut, Holz Frank G, Ach Thomas, Fiorentzis Miltiadis, Bechrakis Nikolaos E, Willerding Gregor D
Augenkompetenz Zentren Heidenheim, 89518 Heidenheim, Germany.
Augenkompetenz Zentren Bopfingen, 73441 Bopfingen, Germany.
Cancers (Basel). 2022 Apr 2;14(7):1809. doi: 10.3390/cancers14071809.
Choroidal melanocytic lesions require reliable and precise clinical examination and diagnosis to differentiate benign choroidal nevi from choroidal melanoma, as the latter may become life-threatening through metastatic disease. To come to an accurate diagnosis, as well as for monitoring, and to assess the efficacy of therapy, various imaging modalities may be used, one of which is non-invasive fundus autofluorescence (FAF) imaging using novel high-resolution digital imaging technology. FAF imaging is based on the visualization of intrinsic fluorophores in the ocular fundus. Lipofuscin and melanolipofuscin within the postmitotic retinal pigment epithelium (RPE) cells represent the major fluorophores that contribute to the FAF signal. In addition, the presence or loss of absorbing molecular constituents may have an impact on the FAF signal. A choroidal melanoma can cause secondary retinal and RPE alterations that affect the FAF signal (e.g., occurrence of orange pigment). Therefore, FAF imaging supports multimodal imaging and gives additional information over and above conventional imaging modalities regarding retinal metabolism and RPE health status. This article summarises the features of FAF imaging and the role of FAF imaging in the context of choroidal melanoma, both before and following therapeutic intervention.
脉络膜黑素细胞性病变需要可靠且精确的临床检查和诊断，以区分良性脉络膜痣和脉络膜黑色素瘤，因为后者可能通过转移性疾病危及生命。为了做出准确诊断以及进行监测，并评估治疗效果，可以使用各种成像方式，其中之一是使用新型高分辨率数字成像技术的非侵入性眼底自发荧光（FAF）成像。FAF成像基于眼底内固有荧光团的可视化。有丝分裂后视网膜色素上皮（RPE）细胞内的脂褐素和黑素脂褐素是构成FAF信号的主要荧光团。此外，吸收性分子成分的存在或缺失可能会影响FAF信号。脉络膜黑色素瘤可引起继发性视网膜和RPE改变，从而影响FAF信号（例如橙色色素的出现）。因此，FAF成像支持多模态成像，并在视网膜代谢和RPE健康状况方面提供了超越传统成像方式的额外信息。本文总结了FAF成像的特点以及FAF成像在脉络膜黑色素瘤治疗干预前后的背景下所起的作用。
