Jamnicky B, Slijepcević M, Hadzija M, Juretić D, Borcić O
Pliva Research Institute, Zagreb, Yugoslavia.
Acta Diabetol Lat. 1991 Jan-Mar;28(1):11-8. doi: 10.1007/BF02732109.
The metabolism of tryptophan (TRP) was studied in diabetic and insulin-treated diabetic rats throughout a five-month period. In alloxan diabetic rats the serum and brain TRP levels were decreased (serum: 38 to 48 mmol/l, brain: 8.6 to 9.2 mmol/g) in comparison to the values of control rats (serum: 59 to 64 mmol/l, brain: 11.3 to 12.6 mmol/g). Daily long-term (for 45, 75, 90 or 135 days) treatment with intermediately acting insulin (4 IU/rat, s.c.) was not able to restore brain concentration of TRP. On the contrary, the serum TRP concentrations were totally or partially restored. The concentrations of branched chain amino acids (BCAA) were increased in serum (valine = 361.2 to 461.0 mumol/l or leucine + isoleucine = 431.0 to 520.3 mumol/l) throughout the entire five-month examination period. Insulin treatment did not return serum concentration of BCAA to normal level in the observation period either.
在五个月的时间里，对糖尿病大鼠和胰岛素治疗的糖尿病大鼠的色氨酸（TRP）代谢进行了研究。与对照大鼠的值（血清：59至64 mmol/l，脑：11.3至12.6 mmol/g）相比，四氧嘧啶糖尿病大鼠的血清和脑TRP水平降低（血清：38至48 mmol/l，脑：8.6至9.2 mmol/g）。每日长期（45、75、90或135天）用中效胰岛素（4 IU/大鼠，皮下注射）治疗不能恢复脑TRP浓度。相反，血清TRP浓度完全或部分恢复。在整个五个月的检查期间，血清中支链氨基酸（BCAA）的浓度升高（缬氨酸 = 361.2至461.0 μmol/l或亮氨酸 + 异亮氨酸 = 431.0至520.3 μmol/l）。在观察期内，胰岛素治疗也未使血清BCAA浓度恢复到正常水平。
