Le Bouteiller P, Daëron M, Duc H T, Righenzi S, Voisin G A
Eur J Immunol. 1976 May;6(5):326-32. doi: 10.1002/eji.1830060505.
The present paper describes an ultrastructural study of two different kinds of behavior of mouse mast cells during two immunological reactions induced by transplantation antibodies: the direct allogeneic anaphylactic degranulation and the serocytotoxicity. In both situations, the same alloantigens, born by the mast cells themselves, are the targets of the reaction, but the first one is mediated by anaphylactic alloantibodies whereas the second one is mediated by cytotoxic alloantibodies in the presence of complement. The comparison of the ultrastructural aspects of the cells in these two systems demonstrated that mast cells can behave in two different ways depending on the nature of the immunological agents utilized. First, a physiological degranulation process with active granule expulsion was observed. This process was shown to be identical to the one induced in classical in vitro anaphylaxis or by histamine releasers such as compound 48/80. A second type of behavior was a lethal, complement-dependent, cell lysis without active granule expulsion.
本文描述了在移植抗体诱导的两种免疫反应过程中，对小鼠肥大细胞两种不同行为的超微结构研究：直接同种异体过敏脱颗粒和血清细胞毒性。在这两种情况下，肥大细胞自身携带的相同同种抗原是反应的靶标，但第一种情况由过敏同种抗体介导，而第二种情况在补体存在下由细胞毒性同种抗体介导。对这两个系统中细胞超微结构方面的比较表明，肥大细胞的行为方式可能因所使用免疫剂的性质而有所不同。首先，观察到一个伴有活性颗粒排出的生理性脱颗粒过程。该过程被证明与经典体外过敏反应或由组胺释放剂如化合物48/80诱导的过程相同。第二种行为类型是一种致命的、补体依赖性的、无活性颗粒排出的细胞裂解。
