Daëron M, Kanellopoulos J, Duc H T, Kinsky R, Voisin G A
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):61-3.
Because mast cells from inbred mice possess both H-2 Ag and Fe receptors they can be degranulated by anaphylactic allo-Ab (DAAD). Beside IgG1, IgE allo-Ab were shown to exist and to be able to achieve DAAD. So far, to be the target of DAAD, an Ag must be present on the mast cell membrane and presumably not linked to the Fe receptor. The mechanism of DAAD involves very likely a double interaction of the Ab (by its two reactive ends) with the mast cell membrane.
由于近交系小鼠的肥大细胞同时具有H-2抗原和铁受体，它们可被过敏性同种抗体（DAAD）脱颗粒。除IgG1外，已证明IgE同种抗体也存在且能够实现DAAD。到目前为止，作为DAAD的靶标，抗原必须存在于肥大细胞膜上，并且推测不与铁受体相连。DAAD的机制很可能涉及抗体（通过其两个反应端）与肥大细胞膜的双重相互作用。
