Mulhare P E, Tracy P B, Golden E A, Branda R F, Bovill E G
Department of Pathology, University of Vermont, College of Medicine, Burlington 05405.
Am J Clin Pathol. 1991 Aug;96(2):196-200. doi: 10.1093/ajcp/96.2.196.
A 67-year-old woman had symptoms of an upper respiratory tract infection for which she received a five-day course of erythromycin. Epistaxis and gross hematuria subsequently developed, and the patient was found to have a selective Factor X deficiency. She received supportive therapy and prothrombin complex concentrates (Factors II, VII, IX, and X), with subsequent resolution of her transient Factor X deficiency. Her hospital course, however, was complicated by the development of multiple cerebral infarctions. This is the tenth reported case of transient Factor X deficiency not associated with amyloidosis. In seven of the previous cases, as in this patient, the deficiency was associated with a preceding upper respiratory infection. This is the only case, however, with evidence of inhibitory activity in the plasma that was directed toward Factor X.
一名67岁女性出现上呼吸道感染症状，为此接受了为期五天的红霉素治疗。随后出现鼻出血和肉眼血尿，该患者被发现存在选择性因子X缺乏。她接受了支持性治疗和凝血酶原复合物浓缩剂（因子II、VII、IX和X），随后其短暂性因子X缺乏得到缓解。然而，她的住院病程因多发性脑梗死的发生而变得复杂。这是第十例报告的与淀粉样变性无关的短暂性因子X缺乏病例。在之前的七例病例中，与该患者一样，缺乏与先前的上呼吸道感染有关。然而，这是唯一一例血浆中存在针对因子X的抑制活性证据的病例。
