Hearn Y R, Gander R M
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Am J Clin Pathol. 1991 Aug;96(2):211-4. doi: 10.1093/ajcp/96.2.211.
Perinatal acquisition of a rare pediatric pathogen, Achromobacter xylosoxidans, with evidence for in utero transmission, is described. Cultures from the mother and neonate demonstrated A. xylosoxidans. An ascending bacterial infection in the mother with clinical chorioamnionitis is presented as the probable mode of transmission. Postmortem examination of the infant confirmed Achromobacter meningitis. In contrast to the current case with transmission from mother to neonate, previously published neonatal cases of Achromobacter infections indicate that nosocomial transmission of the organism is most common (79%). In addition, the literature review revealed a high mortality associated with meningitis (77%), frequent hydrocephalus, and subsequent neurologic sequelae (36%). To the authors' knowledge, this is the first documented case of maternal-fetal transfer of A. xylosoxidans.
本文描述了围产期感染一种罕见的儿科病原体——木糖氧化无色杆菌，并存在宫内传播的证据。对母亲和新生儿的培养物检测显示存在木糖氧化无色杆菌。母亲发生的伴有临床绒毛膜羊膜炎的上行性细菌感染被认为是可能的传播方式。婴儿的尸检证实为木糖氧化无色杆菌脑膜炎。与当前这例母婴传播的病例不同，先前发表的新生儿木糖氧化无色杆菌感染病例表明，该病原体的医院内传播最为常见（79%）。此外，文献综述显示，脑膜炎相关的死亡率很高（77%），脑积水频繁发生，随后出现神经后遗症的比例为36%。据作者所知，这是首例有记录的木糖氧化无色杆菌母婴传播病例。
