Iakovlev A A, Gutman L B, Mellina I M
Akush Ginekol (Mosk). 1991 Feb(2):34-6.
The plasma levels of prostaglandins A, E, and F2 alpha were measured by the radioimmunoassay in 146 hypertensive and 62 healthy pregnant females. It was ascertained that beginning in the second trimester, the ratio of various prostaglandins is impaired in the direction of increasing values of substances from the pressor group as the hypertensive disease evolves. This is due to lower levels of prostaglandins A and E and/or higher levels of prostaglandins F2 alpha. In associated late gestosis, prostaglandin levels are related to the clinical manifestations of this disease. There are increased prostaglandin F2 alpha concentrations with severe nephropathy. The studies indicate that prostaglandins affect the course of hypertensive disease in pregnant women and the development of associated late gestosis.
采用放射免疫分析法测定了146例高血压孕妇和62例健康孕妇血浆中前列腺素A、E和F2α的水平。已确定，从妊娠中期开始，随着高血压疾病的发展，各种前列腺素的比例朝着升压组物质值增加的方向受损。这是由于前列腺素A和E水平较低和/或前列腺素F2α水平较高。在相关的晚期妊娠中毒症中，前列腺素水平与该疾病的临床表现有关。严重肾病时前列腺素F2α浓度升高。研究表明，前列腺素影响孕妇高血压疾病的病程及相关晚期妊娠中毒症的发展。
