Takahashi Tsutomu, Suzuki Michio, Tsunoda Masahiko, Kawamura Yukiko, Takahashi Nagahide, Tsuneki Hiroshi, Kawasaki Yasuhiro, Zhou Shi-Yu, Kobayashi Soushi, Sasaoka Toshiyasu, Seto Hikaru, Kurachi Masayoshi, Ozaki Norio
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Neurosci Lett. 2008 Apr 11;435(1):34-9. doi: 10.1016/j.neulet.2008.02.004. Epub 2008 Feb 9.
Magnetic resonance imaging was used to investigate the relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric measurements for the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) and prefrontal sub-regions (the superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, ventral medial prefrontal cortex, orbitofrontal cortex, and straight gyrus) in a Japanese sample of 33 schizophrenia patients and 29 healthy subjects. For the controls, the Met carriers had significantly smaller parahippocampal and left superior frontal gyri than the Val homozygotes. The schizophrenia patients carrying the Met allele had a significantly smaller right parahippocampal gyrus than those with the Val/Val genotype, but the genotype did not affect the prefrontal regions in schizophrenia patients. These findings might reflect different genotypic effects of BDNF on brain morphology in schizophrenia patients and healthy controls, implicating the possible role of the brain morphology as an endophenotype for future genetic studies in schizophrenia.
采用磁共振成像技术，在33例精神分裂症患者和29名健康受试者的日本样本中，研究脑源性神经营养因子（BDNF）Val66Met多态性与内侧颞叶结构（杏仁核、海马体和海马旁回）及前额叶亚区域（额上回、额中回、额下回、腹内侧前额叶皮质、眶额皮质和直回）体积测量值之间的关系。对于对照组，携带Met等位基因者的海马旁回和左侧额上回明显小于Val纯合子。携带Met等位基因的精神分裂症患者的右侧海马旁回明显小于Val/Val基因型患者，但该基因型对精神分裂症患者的前额叶区域无影响。这些发现可能反映了BDNF在精神分裂症患者和健康对照中对脑形态的不同基因型效应，提示脑形态可能作为精神分裂症未来遗传学研究的一种内表型发挥作用。
