Ludewick Herbert P, Schwab Sibylle G, Albus Margot, Lerer Bernard, Maier Wolfgang, Trixler Matyas, Wildenauer Dieter B
Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia.
Psychiatr Genet. 2008 Aug;18(4):208-10. doi: 10.1097/YPG.0b013e3283050aba.
Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3' flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.
痕量胺相关受体6基因及其3'侧翼区域的单核苷酸多态性（SNP）已被证明与精神分裂症有关。为了重复这些研究结果，我们在79个同胞对家庭（56/79个同胞对家庭显示与6q23连锁）和125个三联体样本中，对五个最显著的SNP进行了基于家系的关联研究。在我们的样本中，即使仅限于56个连锁家庭，这些SNP与精神分裂症之间也未获得关联证据（P>0.2）。我们得出结论，在我们的家系样本中，痕量胺相关受体6对精神分裂症的发生并不重要。
