在爱尔兰精神分裂症病例对照研究（ICCSS）样本中，痕量胺相关受体（TAAR6）基因与精神分裂症无关。
The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
作者信息
Vladimirov Vladimir I, Maher Brion S, Wormley Brandon, O'Neill F Anthony, Walsh Dermot, Kendler Kenneth S, Riley Brien P
机构信息
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 East Leigh Street, Biotech 1-110, Richmond VA 23298, USA.
出版信息
Schizophr Res. 2009 Feb;107(2-3):249-54. doi: 10.1016/j.schres.2008.09.030. Epub 2008 Oct 30.
Abstract
To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Density Schizophrenia Families (ISHDSF) sample, we genotyped 12 single nucleotide polymorphisms (SNPs) in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. Only rs9389020 provided nominal evidence for association (p<0.0228), which did not withstand the permutation testing (p<0.2196). The combined odds ratio from ISHDSF and ICCSS samples [OR (95%CI)=1.0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample.
摘要
为了重复先前关于TAAR6与精神分裂症之间的关联，包括我们自己在爱尔兰高密度精神分裂症家族研究（ISHDSF）样本中的发现，我们在爱尔兰精神分裂症病例对照研究（ICCSS）样本中对12个单核苷酸多态性（SNP）进行了基因分型。只有rs9389020提供了名义上的关联证据（p<0.0228），但该证据未能通过置换检验（p<0.2196）。ISHDSF和ICCSS样本的合并比值比[OR（95%CI）=1.0564（1.0078-1.1074）；p=0.02]，虽然名义上具有显著性，但在多重检验校正后并不显著。在这里，我们证明在ICCSS样本中TAAR6与精神分裂症无关。
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