Das Sunit, Srikanth Maya, Kessler John A
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 675 North Saint Clair Street, Suite 2210, Chicago, IL 60611, USA.
Nat Clin Pract Neurol. 2008 Aug;4(8):427-35. doi: 10.1038/ncpneuro0862. Epub 2008 Jul 15.
Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. According to the CSC hypothesis, current therapies that are extremely cytotoxic to the bulk of highly proliferative tumor cells fail to obliterate the relatively quiescent and resistant CSC compartment, thereby allowing these cells to survive and drive tumor recurrence. This Review summarizes current knowledge regarding neural stem cells in the normal adult brain and CSCs in glial tumors and discusses the implications of the CSC hypothesis for the development of future therapies for brain tumors.
尽管手术和药物治疗不断取得进展，但多形性胶质母细胞瘤患者的预后仍然很差。最近的数据表明，这些脑肿瘤的进展是由一小部分肿瘤细胞驱动的，这些细胞被称为癌症干细胞（CSCs），因为它们具有自我更新、增殖和产生多种神经上皮谱系后代的能力。根据癌症干细胞假说，目前对大量高度增殖肿瘤细胞具有极强细胞毒性的疗法无法消除相对静止和耐药的癌症干细胞群，从而使这些细胞得以存活并驱动肿瘤复发。本综述总结了关于正常成人大脑中神经干细胞和胶质肿瘤中癌症干细胞的现有知识，并讨论了癌症干细胞假说对未来脑肿瘤治疗发展的影响。
