Schäfer Matthias, Werner Sabine
Institute of Cell Biology, ETH Zürich, Schafmattstrasse 18, 8093 Zürich, Switzerland.
Nat Rev Mol Cell Biol. 2008 Aug;9(8):628-38. doi: 10.1038/nrm2455. Epub 2008 Jul 16.
What is the relationship between the wound-healing process and the development of cancer? Malignant tumours often develop at sites of chronic injury, and tissue injury has an important role in the pathogenesis of malignant disease, with chronic inflammation being the most important risk factor. The development and functional characterization of genetically modified mice that lack or overexpress genes that are involved in repair, combined with gene-expression analysis in wounds and tumours, have highlighted remarkable similarities between wound repair and cancer. However, a few crucial differences were also observed, which could account for the altered metabolism, impaired differentiation capacity and invasive growth of malignant tumours.
伤口愈合过程与癌症发展之间有什么关系？恶性肿瘤常常在慢性损伤部位发生，并且组织损伤在恶性疾病的发病机制中起着重要作用，慢性炎症是最重要的风险因素。缺乏或过度表达参与修复的基因的转基因小鼠的发育及功能特性，再结合伤口和肿瘤中的基因表达分析，突出了伤口修复与癌症之间的显著相似性。然而，也观察到了一些关键差异，这可能解释了恶性肿瘤代谢改变、分化能力受损和侵袭性生长的原因。
