Karhana Sonali, Samim Mohd, Khan Mohd Ashif
Department of Translational & Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, 110062, India.
Department of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.
Arch Dermatol Res. 2025 Jan 28;317(1):311. doi: 10.1007/s00403-024-03785-5.
The area of wound healing presents a promising field of interest for clinicians as well as the scientific community. A major concern for physicians is the rising number of elderly people suffering from diabetes, leprosy, tuberculosis and the associated chronic wounds. While traditional therapies target basic wound care, innovative strategies that accelerate wound healing are needed. V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors are anti-cancer drugs used primarily for melanoma. They also exhibit paradoxical activity, a phenomenon characterized by unintended activation of the Mitogen-Activated Protein Kinase (MAPK) signalling pathway leading to skin hyperproliferation. Studies have demonstrated that BRAF inhibitors can be repurposed to accelerate the healing of acute and chronic wounds by exploiting their paradoxical activity. This review evaluates studies on BRAF inhibitors by employing a systematic search strategy using databases such as PubMed, Scopus, Google Scholar, and Web of Science. Articles were screened based on relevance to the paradoxical activity of BRAF inhibitors, their mechanisms, and applications in wound healing. Evidence from in vitro, in vivo, and clinical studies demonstrates that BRAF inhibitors can enhance processes such as epithelialization and angiogenesis, essential for wound repair. This review summarizes the reports on the paradoxical activity of BRAF inhibitors, the predicted mechanisms behind the paradoxical activity, and their potential use in wound healing.
伤口愈合领域对临床医生和科学界来说都是一个充满前景的研究方向。医生们主要关注的是患糖尿病、麻风病、结核病以及相关慢性伤口的老年人数量不断增加。虽然传统疗法侧重于基本的伤口护理，但仍需要能加速伤口愈合的创新策略。V-RAF鼠肉瘤病毒癌基因同源物B1（BRAF）抑制剂是主要用于治疗黑色素瘤的抗癌药物。它们还表现出矛盾活性，这是一种以丝裂原活化蛋白激酶（MAPK）信号通路意外激活导致皮肤过度增殖为特征的现象。研究表明，BRAF抑制剂可通过利用其矛盾活性来重新用于加速急性和慢性伤口的愈合。本综述通过使用PubMed、Scopus、谷歌学术和科学网等数据库的系统检索策略，对BRAF抑制剂的研究进行了评估。根据与BRAF抑制剂矛盾活性、其作用机制以及在伤口愈合中的应用的相关性对文章进行筛选。来自体外、体内和临床研究的证据表明，BRAF抑制剂可增强上皮形成和血管生成等对伤口修复至关重要的过程。本综述总结了关于BRAF抑制剂矛盾活性的报告、矛盾活性背后的预测机制以及它们在伤口愈合中的潜在用途。
