Strawbridge Rona J, Nister Monica, Brismar Kerstin, Li Chunde, Lindström Sara
Department of Oncology Pathology, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.
Eur J Hum Genet. 2008 Dec;16(12):1521-5. doi: 10.1038/ejhg.2008.131. Epub 2008 Jul 16.
Gene expression profiling has identified MUC1 as being significantly overexpressed in prostate cancer with poor clinical outcome after radical surgery, but the molecular mechanisms are still unclear. In this paper, we examined whether the genetic variation in MUC1 alters prostate cancer risk and progression. We identified five haplotype-tagging single-nucleotide polymorphisms that describe inherited genetic variation in and around MUC1. Individual single-nucleotide polymorphisms as well as haplotypes were tested for association with prostate cancer risk and prognosis in 2760 cases and 1722 controls from the Swedish population. We found no association between any single-nucleotide polymorphism or haplotype in the MUC1 and risk of prostate cancer. Stratifying for disease severity or age of onset did not alter the results. Moreover, we observed no association with MUC1 variation and prostate cancer-specific survival. Common variants in MUC1 and the surrounding region are not associated with risk or prognosis of prostate cancer in Swedish men.
基因表达谱分析已确定MUC1在根治性手术后临床预后较差的前列腺癌中显著过表达，但其分子机制仍不清楚。在本文中，我们研究了MUC1的基因变异是否会改变前列腺癌的风险和进展。我们鉴定出五个标签单核苷酸多态性，它们描述了MUC1及其周围的遗传变异。对来自瑞典人群的2760例病例和1722例对照进行个体单核苷酸多态性以及单倍型与前列腺癌风险和预后的关联性检测。我们发现MUC1中的任何单核苷酸多态性或单倍型与前列腺癌风险之间均无关联。按疾病严重程度或发病年龄分层并未改变结果。此外，我们未观察到MUC1变异与前列腺癌特异性生存率之间存在关联。MUC1及其周围区域的常见变异与瑞典男性前列腺癌的风险或预后无关。
