Smith Barry, Kumar Anand, Ceusters Werner, Rosse Cornelius
Ifomis University of Saarbröcken Germany.
Comp Funct Genomics. 2005;6(7-8):379-87. doi: 10.1002/cfg.497.
Tumours, abscesses, cysts, scars and fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas.
肿瘤、脓肿、囊肿、瘢痕和骨折是我们所称的病理持续实体的常见类型。这些类型的实例总是存在于解剖结构之中或之上，解剖结构由此转变为相应类型的病理解剖结构：骨折的胫骨、起水疱的拇指、患癌的结肠。在之前关于生物医学本体论的工作中，我们展示了为诸如is_a（属于）、part_of（是……的一部分）和transformation_of（转变为）等关系提供形式化定义，如何能够以有可能支持新型自动推理的方式促进此类本体论的整合。我们在此将这种方法扩展到病理学的处理，尤其关注器官受到癌症影响时出现的那些病理持续实体。
