[Perioperative dynamics of the parameters of acid-base equilibrium in patients with lung cancer in relation to the type of anesthesia].

Acid-base parameters of the venous blood have been studied in 60 patients with lung cancer randomized into two groups prior to and following lung resection and on days 2, 4 and 9 postoperatively. In group I multicomponent endotracheal anesthesia using controlled lung ventilation and postoperative intramuscular analgesia with non-narcotic and narcotic analgesics were employed. In group II anesthesia and controlled lung ventilation were supplemented by epidural anesthesia with 2.5% trimecaine solution combined with adrenaline and small morphine doses at the upper thoracic segment level, postoperative analgesia for 18 hours was performed likewise. Perioperative acid-base balance changes were found to be more favourable in patients of group II, which was manifested in weaker acidosis by the end of the operation and in the absence of remote pathological changes in the acid-base balance. In patients of group I gradual repeated increase in metabolic acidosis was observed, which by day 9 postoperatively assumed a complicated clinical course.