Grishchenko M N, Mosolova L A, Andrianova M Iu
Anesteziol Reanimatol. 1991 Jan-Feb(1):7-10.
Changes in 2,3-DPG level have been studied in cardiosurgical patients. It has been shown that 2,3-DPG concentration increase, as a moderately fast mechanism in a common model of tissue pO2 regulation, is observed in almost half of patients with acquired heart valve defects. An increase in 2,3-DPG level and P50 value leading to a decrease in hemoglobin affinity to oxygen has been found in one third of patients. It has been established that 2,3-DPG level and P50 value are, as a rule, normal in patients with mitral stenosis, acyanotic congenital heart valve defects and ischemic heart disease. In a number of patients with mitral stenosis an increased Hb concentration, as a slow mechanism of hypoxia compensation in the model of tissue pO2 regulation, is a prevailing mechanism of adaptation to hypoxia.
已对心脏外科手术患者的2,3 - 二磷酸甘油酸（2,3 - DPG）水平变化进行了研究。结果显示，在几乎一半的获得性心脏瓣膜缺损患者中，可观察到2,3 - DPG浓度升高，这是组织氧分压调节常见模式中的一种适度快速机制。在三分之一的患者中发现2,3 - DPG水平和P50值升高，导致血红蛋白对氧的亲和力降低。已确定，二尖瓣狭窄、无青紫型先天性心脏瓣膜缺损和缺血性心脏病患者的2,3 - DPG水平和P50值通常正常。在一些二尖瓣狭窄患者中，血红蛋白浓度升高作为组织氧分压调节模型中缺氧代偿的一种缓慢机制，是适应缺氧的主要机制。
