Oldag D, Gross J, Michel A, Evers G, Schubel B
Acta Biol Med Ger. 1977;36(5-6):665-7.
The behaviour of 2,3-diphosphoglycerate concentration (2,3-DPG) of red blood cells of babies and children with cyanotic heart diseases is studied before and after shunt operations. In babies with cyanotic heart diseases at the age of up to 6 months an increase of 2,3-DPG-level and haematocrit (HCT) is seen. Later, the compensation of chronic hypoxia is effected by further increase of HCT at unchanged high 2,3-DPG-level. The 2,3-DPG concentration which is still increased after successfull shunt operations as compared with the normal value is considered as an effective adaptation mechanism to the residual hypoxia presenting only a small load on the circulatory system. The 2,3-DPG concentration alone does not represent a criterion for the assessment of chronic hypoxia.
研究了患有青紫型心脏病的婴幼儿在分流手术前后红细胞中2,3 - 二磷酸甘油酸浓度（2,3 - DPG）的变化情况。在6个月及以下患有青紫型心脏病的婴儿中，可见2,3 - DPG水平和血细胞比容（HCT）升高。之后，在2,3 - DPG水平持续处于较高状态不变的情况下，通过进一步升高HCT来实现对慢性缺氧的代偿。与正常值相比，成功进行分流手术后2,3 - DPG浓度仍升高，这被认为是对残余缺氧的一种有效适应机制，对循环系统仅造成较小负担。仅2,3 - DPG浓度并不代表评估慢性缺氧的标准。
