Zhdanov G G, Nechaev V N, Alipov P A
Anesteziol Reanimatol. 1991 Mar-Apr(2):54-8.
Hyperbaric oxygenation (HBO) was used in a complex intensive therapy of 194 children, aged 3 days to 3 years, with severe pneumonias. Initially the patients have revealed intensification of free radical processes (FRP) with a simultaneous decrease in the level of enzyme and non-enzyme protection and a drastic increase in gluco- and mineralocorticoid adrenal function. HBO and antioxidants (unithiol and alpha-tocopherol) yielded excellent and good results (a drop in FRP level and activation of enzyme antioxidant protection) in 75.8% of patients. HBO was ineffective in 17% of cases, in 7.2% of patients signs of the developing oxygen intoxication have been revealed. Control over the indexes of erythrocytes resistance to peroxide, extra-erythrocyte hemoglobin, total peroxidase plasma activity during HBO procedure makes it possible to detect early preclinical signs of acute oxygen intoxication onset.
对194名年龄在3天至3岁的重症肺炎患儿进行了高压氧治疗（HBO），作为综合强化治疗的一部分。最初，这些患者表现出自由基过程（FRP）增强，同时酶和非酶保护水平下降，糖皮质激素和盐皮质激素肾上腺功能急剧增加。高压氧治疗和抗氧化剂（二巯基丙醇和α-生育酚）在75.8%的患者中取得了优异和良好的效果（FRP水平下降和酶抗氧化保护激活）。高压氧治疗在17%的病例中无效，7.2%的患者出现了氧中毒发展的迹象。在高压氧治疗过程中，对红细胞对过氧化物的抗性指标、红细胞外血红蛋白、血浆总过氧化物酶活性进行监测，有助于早期发现急性氧中毒发作的临床前迹象。
