Firoozbakhsh Farhad, Mohammadi Fatemeh Haji, Safari Sepide, Khashayar Patricia
Tehran Univ. of Medical Science, Amir Alam Hospital, Tehran, Iran.
Middle East J Anaesthesiol. 2008 Feb;19(4):859-67.
Hypertension is one of the most frequent complication during laryngoscopy and intubation; thus in the premedication or induction stages, many drugs have been used to control this hypertension. Nitroglycerine is one of the drugs thought to be effective and the purpose of this study is to appraise this deliberation.
150 patients of 20-50 years of age were enrolled in this randomized double blind clinical trial. They were randomly divided into two group, one received 2 microg/kg nitroglycerine while the other group did not received any drug. Blood pressure was checked in 3 different stages and compared.
In both groups, pre and post intubation systolic pressure had a significant difference; whereas this relation could not be found for the diastolic pressure. These variables did not have a statistically significant relation prior to intubation; whilst after intubation, a significant relation was elicited.
Injection of 2 microg/kg nitroglycerine immediately after anesthetic induction is effective in preventing the unwanted increase in the blood pressure, and as a result, complications following this response in patients with ischemic heart disease would be reduced.
高血压是喉镜检查和插管过程中最常见的并发症之一；因此，在术前用药或诱导阶段，人们使用了多种药物来控制这种高血压。硝酸甘油被认为是有效的药物之一，本研究的目的是评估这一观点。
150名年龄在20至50岁之间的患者参与了这项随机双盲临床试验。他们被随机分为两组，一组接受2微克/千克硝酸甘油，另一组不接受任何药物。在三个不同阶段检查血压并进行比较。
两组患者插管前后收缩压均有显著差异；而舒张压未发现这种关系。这些变量在插管前无统计学显著关系；而插管后则出现了显著关系。
麻醉诱导后立即注射2微克/千克硝酸甘油可有效预防血压意外升高，从而减少缺血性心脏病患者因这种反应而引发的并发症。
