Batra Y K, Indu B, Puri G D
Department of Anesthesiology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
Int J Clin Pharmacol Ther Toxicol. 1988 Jul;26(7):360-3.
Forty healthy patients (ASA class 1) of both sexes, aged between 20 and 45 years, undergoing routine surgical procedures were included in this double-blind randomized study. They were divided into two groups of 20 each. Patients in group A received no pretreatment, while patients in group B received oral clonidine 5 micrograms kg-1 90 min before induction of anesthesia. All patients received thiopentone (5 mgs kg-1) followed by suxamethonium (1.5 mgs kg-1) to facilitate endotracheal intubation. Control patients showed a significant increase in heart rate and blood pressure; they were significantly lower in the clonidine treated group immediately after intubation (p less than 0.001). The data suggest that the rise in heart rate and blood pressure associated with laryngoscopy and intubation during a routine induction sequence can be attenuated by the use of oral clonidine.
本双盲随机研究纳入了40例年龄在20至45岁之间、接受常规外科手术的健康患者（ASA 1级），男女不限。他们被分为两组，每组20人。A组患者未接受预处理，而B组患者在麻醉诱导前90分钟口服可乐定5微克/千克。所有患者均接受硫喷妥钠（5毫克/千克），随后接受琥珀酰胆碱（1.5毫克/千克）以利于气管插管。对照组患者心率和血压显著升高；插管后立即在可乐定治疗组中显著降低（p<0.001）。数据表明，在常规诱导过程中，与喉镜检查和插管相关的心率和血压升高可通过口服可乐定得到减轻。
