Reisberg Barry, Prichep Leslie, Mosconi Lisa, John E Roy, Glodzik-Sobanska Lidia, Boksay Istvan, Monteiro Isabel, Torossian Carol, Vedvyas Alok, Ashraf Nauman, Jamil Imran A, de Leon Mony J
Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA.
Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S98-S108. doi: 10.1016/j.jalz.2007.11.017.
Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons.
The past and the emerging literature on SCI and synonymously named conditions is reviewed.
Findings include: (1) There is support from at least one longitudinal study for a long-standing concept of SCI as a pre-mild cognitive impairment (MCI) condition lasting approximately 15years. (2) There are complex relationships between SCI and depression and anxiety. (3) Differences in SCI subjects from age-matched non-SCI persons are being published in terms of cognitive tests, hippocampal gray matter density, hippocampal volumes, cerebral metabolism, and urinary cortisol levels. Psychometric and dementia test score differences between SCI and MCI subjects have long been evident. (4) Predictive electrophysiologic features of subsequent decline in SCI subjects are being published.
Studies of therapeutic agents in SCI treatment and resultant Alzheimer's disease prevention appear to be feasible. These trials are also necessary from a public health perspective.
主观认知障碍（SCI）是一种常见但了解不足的状况，在老年人中经常出现。
回顾了关于SCI及同义命名状况的过去和新兴文献。
研究结果包括：（1）至少有一项纵向研究支持SCI作为一种持续约15年的轻度认知障碍（MCI）前期状况的长期概念。（2）SCI与抑郁和焦虑之间存在复杂关系。（3）在认知测试、海马灰质密度、海马体积、脑代谢和尿皮质醇水平方面，SCI受试者与年龄匹配的非SCI人群之间的差异正在被发表。SCI和MCI受试者之间的心理测量和痴呆测试分数差异长期以来一直很明显。（4）SCI受试者随后衰退的预测性电生理特征正在被发表。
对治疗药物在SCI治疗及由此预防阿尔茨海默病方面的研究似乎是可行的。从公共卫生角度来看，这些试验也是必要的。
