日常认知量表（ECog-12）短版检测认知障碍的性能。
Performance of a Short Version of the Everyday Cognition Scale (ECog-12) to Detect Cognitive Impairment.
机构信息
Rachel L. Nosheny, Ph.D., Assistant Professor, University of California, San Francisco, Department of Psychiatry, San Francisco VA Medical Center, 4150 Clement Street (114M), San Francisco, CA 94121, Tel: 650-468-0619, Fax: 415-668-2864, email:
出版信息
J Prev Alzheimers Dis. 2024;11(6):1741-1750. doi: 10.14283/jpad.2024.109.
BACKGROUND
The Everyday Cognition (ECog) 12-item scale, a functional decline measurement, can distinguish dementia from cognitively unimpaired (CU). Limited data compare ECog-12 performance by raters (self vs. informant) and scoring systems (average numeric vs. categorical grouping) to differentiate cognitive statuses.
OBJECTIVES
To evaluate the performance of ECog-12 in differentiation cognitive statuses.
DESIGN
A cross-sectional diagnostic test study.
SETTING AND PARTICIPANTS
Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study are analyzed. Participants were aged 55-90 years old divided into subgroups based on diagnostic criteria.
MEASUREMENTS
We evaluated ECog-12 performance across different diagnostic groups, such as CU vs cognitive impairment (CI; mild cognitive impairment (MCI), and dementia), and the association between ECog-12 and CI. This procedure was repeated for self- and partner (informant)-reports. Additionally, types of ECog scores were also assessed, where an average ECog score was calculated (continuous numeric) as well as a categorical grouping ("any occasional declined" or "any consistently declined") based on item-level responses to ECog questions.
RESULTS
ECog-12 cut-off scores of 1.36 (self-reported) and 1.45 (partner-reported) distinguish CU from CI with AUC 0.7 and 0.78, respectively. Adding a memory-concern question improved self-reported-ECog AUC to 0.79. Self- and partner-reported "consistently-declined" ECog-12 categorical grouping provided AUC 0.69 and 0.78. The study partner reported ECog-12 showed a greater association with CI than self-reported, with odds ratios of 35.45 and 8.79, respectively.
CONCLUSION
Study partner-reported ECog scores performed better than self-reported ECog-12 in differentiating cognitive statuses, and a higher study partner reported ECog score was a higher prognostic risk for CI. A memory concern question could enhance self-reported ECog-12 performance. This further emphasizes the need to obtain data from study partners for research and clinical practice.
背景
日常认知（ECog）12 项量表是一种衡量功能下降的方法，可以将痴呆与认知正常（CU）区分开来。目前关于评估者（自我报告与知情者报告）和评分系统（平均数值与分类分组）对 ECog-12 表现的比较数据有限，这些数据可用于区分认知状态。
目的
评估 ECog-12 在区分认知状态方面的性能。
设计
一项横断面诊断测试研究。
地点和参与者
分析来自阿尔茨海默病神经影像学倡议（ADNI）研究的数据。参与者年龄在 55-90 岁之间，根据诊断标准分为亚组。
测量方法
我们评估了 ECog-12 在不同诊断组中的表现，例如 CU 与认知障碍（CI；轻度认知障碍（MCI）和痴呆），以及 ECog-12 与 CI 之间的相关性。这一过程在自我报告和伴侣（知情者）报告中重复进行。此外，还评估了 ECog 评分的类型，包括计算 ECog 的平均得分（连续数值）以及根据 ECog 问题的项目水平回答进行分类分组（“偶尔下降”或“持续下降”）。
结果
ECog-12 的截断值为 1.36（自我报告）和 1.45（伴侣报告），分别用于区分 CU 与 CI，曲线下面积（AUC）分别为 0.7 和 0.78。添加记忆问题可将自我报告的 ECog-AUC 提高至 0.79。自我报告和伴侣报告的“持续下降”ECog-12 分类分组的 AUC 分别为 0.69 和 0.78。与自我报告相比，研究伴侣报告的 ECog-12 与 CI 的相关性更强，优势比分别为 35.45 和 8.79。
结论
研究伴侣报告的 ECog 评分在区分认知状态方面优于自我报告的 ECog-12，且研究伴侣报告的 ECog 评分越高，CI 的预后风险越高。添加记忆问题可提高自我报告的 ECog-12 表现。这进一步强调了在研究和临床实践中需要从研究伴侣那里获取数据。
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