瘦素受体基因Lys656Asn多态性对2型糖尿病患者胰岛素抵抗的影响
Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.
作者信息
de Luis D A, Gonzalez Sagrado M, Aller R, Izaola O, Conde R
机构信息
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
出版信息
Diabetes Res Clin Pract. 2008 Sep;81(3):e9-e11. doi: 10.1016/j.diabres.2008.06.002. Epub 2008 Jul 15.
Abstract
This is a descriptive study in diabetic patients. Mutant type patient (39%) (Lys656/Asn656 or Asn656/Asn656) group had higher fat mass, HOMA, CRP and leptin than wild type. Adiponectin levels were lower in mutant type group than wild type (61%) (Lys656/Lys656).
摘要
这是一项针对糖尿病患者的描述性研究。突变型患者（39%）（Lys656/Asn656或Asn656/Asn656）组的脂肪量、稳态模型评估胰岛素抵抗指数（HOMA）、C反应蛋白（CRP）和瘦素水平高于野生型。突变型组的脂联素水平低于野生型（61%）（Lys656/Lys656）。
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