Grinsztejn Beatriz, Veloso Valdilea Gonçalves, Levi José Eduardo, Velasque Luciane, Luz Paula Mendes, Friedman Ruth Khalili, Andrade Angela Cristina, Moreira Ronaldo Ismerio, Russomano Fabio, Pilotto José Henrique, Bastos Francisco Inacio, Palefsky Joel
Instituto de Pesquisa Clínica Evandro Chagas (IPEC), Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Int J Infect Dis. 2009 Jan;13(1):72-80. doi: 10.1016/j.ijid.2008.03.031. Epub 2008 Jul 15.
Human papillomavirus (HPV) infection is a major risk factor for cervical disease. Using baseline data from the HIV-infected cohort of Evandro Chagas Clinical Research Institute at Fiocruz, Rio de Janeiro, Brazil, factors associated with an increased prevalence of HPV were assessed.
Samples from 634 HIV-infected women were tested for the presence of HPV infection using hybrid capture II and polymerase chain reaction. Prevalence ratios (PR) were estimated using Poisson regression analysis with robust variance.
The overall prevalence of HPV infection was 48%, of which 94% were infected with a high-risk HPV. In multivariate analysis, factors independently associated with infection with high-risk HPV type were: younger age (<30 years of age; PR 1.5, 95% confidence interval (CI) 1.1-2.1), current or prior drug use (PR 1.3, 95% CI 1.0-1.6), self-reported history of HPV infection (PR 1.2, 95% CI 0.96-1.6), condom use in the last sexual intercourse (PR 1.3, 95% CI 1.1-1.7), and nadir CD4+ T-cell count <100cells/mm(3) (PR 1.6, 95% CI 1.2-2.1).
The estimated prevalence of high-risk HPV-infection among HIV-infected women from Rio de Janeiro, Brazil, was high. Close monitoring of HPV-related effects is warranted in all HIV-infected women, in particular those of younger age and advanced immunosuppression.
人乳头瘤病毒（HPV）感染是宫颈疾病的主要危险因素。利用巴西里约热内卢奥斯瓦尔多·克鲁兹基金会埃万德罗·查加斯临床研究所HIV感染队列的基线数据，评估与HPV患病率增加相关的因素。
使用杂交捕获II和聚合酶链反应对634名HIV感染女性的样本进行HPV感染检测。采用具有稳健方差的泊松回归分析估计患病率比（PR）。
HPV感染的总体患病率为48%，其中94%感染的是高危HPV。在多变量分析中，与高危HPV类型感染独立相关的因素有：年龄较小（<30岁；PR 1.5，95%置信区间（CI）1.1 - 2.1）、当前或既往有药物使用史（PR 1.3，95% CI 1.0 - 1.6）、自我报告的HPV感染史（PR 1.2，95% CI 0.96 - 1.6）、最近一次性交时使用避孕套（PR 1.3，95% CI 1.1 - 1.7）以及最低CD4 + T细胞计数<100个细胞/mm³（PR 1.6，95% CI 1.2 - 2.1）。
巴西里约热内卢HIV感染女性中高危HPV感染的估计患病率较高。对所有HIV感染女性，尤其是年龄较小和免疫抑制严重的女性，有必要密切监测HPV相关影响。
