Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belém, Brazil.
Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Front Public Health. 2021 Apr 29;9:649152. doi: 10.3389/fpubh.2021.649152. eCollection 2021.
Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. Several studies have shown a higher prevalence of HPV infection in HIV-infected women. The aim of this study was to determine the prevalence and the genotype diversity of HPV infection in HIV-infected women. From April 2010 to December 2012 cervical specimens were collected from 169 HIV-infected women who screening for cervical cancer at Reference Unit in Belém. The detection of HPV infection was performed by nested PCR and HPV type was performed using a commercial system. The prevalence of HPV infection was 63.3%. Of the 47 genotyped samples, 40.4% was found positive for high risk-HPV 16 and 12.8% for high risk-HPV 52. HPV infection was predominant in the group of women with no incidence of cytological abnormalities and more prevalent in women of reproductive age, unmarried, low education level, and who reported use condoms during sexual intercourse. It was observed an association between HPV infection and independent variables, such as condom use, multiple sexual partners, and history of sexually transmitted diseases. High-risk types of HPV infection were prevalent in our study. Infection with multiple high-risk HPV genotypes may potentiate the development of cervical cancer in HIV-infected women.
人乳头瘤病毒（HPV）是世界上最常见的性传播感染。多项研究表明，HIV 感染者中 HPV 感染的患病率更高。本研究旨在确定 HIV 感染者中 HPV 感染的流行率和基因型多样性。2010 年 4 月至 2012 年 12 月，从贝伦参考单位筛查宫颈癌的 169 名 HIV 感染者中采集了宫颈标本。通过巢式 PCR 检测 HPV 感染，使用商业系统检测 HPV 型别。HPV 感染的流行率为 63.3%。在 47 个基因分型样本中，40.4%为高危型 HPV 16 阳性，12.8%为高危型 HPV 52 阳性。HPV 感染在无细胞学异常的女性中更为常见，在生育年龄的女性中更为常见，在未婚、教育程度低、报告性行为中使用避孕套的女性中更为常见。HPV 感染与避孕套使用、多个性伴侣和性传播疾病史等独立变量之间存在相关性。在我们的研究中，高危型 HPV 感染较为普遍。感染多种高危型 HPV 基因型可能会增加 HIV 感染者宫颈癌的发展风险。
