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巧克力作为一种止咳剂:即将开展的一项临床试验的理论依据和理由。

Chocolate as a cough suppressant: rationale and justification for an upcoming clinical trial.

作者信息

Halfdanarson Thorvardur R, Jatoi Aminah

机构信息

Department of Oncology, Mayo Clinic, Rochester, MN.

出版信息

Support Cancer Ther. 2007 Jan 1;4(2):119-22. doi: 10.3816/SCT.2007.n.006.

DOI:10.3816/SCT.2007.n.006
PMID:18632476
Abstract

Cough is a troubling symptom for many patients with cancer. Current cough suppressants can cause side effects and, at the same time, might not provide absolute cough palliation. Suprisingly, accumulating evience suggests that dark chocolate can carry antitussive effects. Although mechanisms remain unknown, it is thought that theobromine, a methylxanthine intrinsic to dark chocolate, might potentially suppress cough. To date, clinical trials with dark chocolate have not been undertaken. This article describes an upcoming trial to determine whether dark chocolate might serve as an antitussive in patients with cancer.

摘要

咳嗽是许多癌症患者困扰的症状。目前的止咳药会引起副作用,同时可能无法完全缓解咳嗽。令人惊讶的是,越来越多的证据表明黑巧克力具有镇咳作用。尽管其机制尚不清楚,但人们认为黑巧克力中含有的甲基黄嘌呤可可碱可能具有潜在的镇咳作用。迄今为止,尚未进行关于黑巧克力的临床试验。本文介绍了一项即将开展的试验,以确定黑巧克力是否可作为癌症患者的止咳药。

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1
Chocolate as a cough suppressant: rationale and justification for an upcoming clinical trial.巧克力作为一种止咳剂:即将开展的一项临床试验的理论依据和理由。
Support Cancer Ther. 2007 Jan 1;4(2):119-22. doi: 10.3816/SCT.2007.n.006.
2
Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial.慢性摄入黑巧克力可增强认知功能并释放神经生长因子:一项平行组随机试验。
Nutrients. 2019 Nov 16;11(11):2800. doi: 10.3390/nu11112800.
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Methylxanthines are the psycho-pharmacologically active constituents of chocolate.甲基黄嘌呤是巧克力中具有精神药理活性的成分。
Psychopharmacology (Berl). 2004 Nov;176(3-4):412-9. doi: 10.1007/s00213-004-1898-3. Epub 2004 May 5.
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Methylxanthine composition and consumption patterns of cocoa and chocolate products.可可和巧克力产品中的甲基黄嘌呤成分及消费模式。
Prog Clin Biol Res. 1984;158:149-78.
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Potential future therapies for the management of cough: ACCP evidence-based clinical practice guidelines.咳嗽管理的潜在未来疗法:美国胸科医师学会循证临床实践指南
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High levels of methylxanthines in chocolate do not alter theobromine disposition.巧克力中高水平的甲基黄嘌呤不会改变可可碱的代谢情况。
Clin Pharmacol Ther. 1985 Apr;37(4):415-24. doi: 10.1038/clpt.1985.65.
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Codeine: A Relook at the Old Antitussive.可待因:对一种老牌镇咳药的重新审视。
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Theobromine inhibits sensory nerve activation and cough.可可碱可抑制感觉神经激活及咳嗽。
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Reinforcing effects of caffeine and theobromine as found in chocolate.巧克力中所含咖啡因和可可碱的强化作用。
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Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines.止咳与药物性镇咳治疗:美国胸科医师学会循证临床实践指南
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Anti-inflammatory, expectorant, and antitussive properties of in ICR mice.
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Theobromine inhibits uric acid crystallization. A potential application in the treatment of uric acid nephrolithiasis.可可碱可抑制尿酸结晶。在治疗尿酸肾结石方面具有潜在应用价值。
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Health benefits of methylxanthines in cacao and chocolate.可可和巧克力中甲基黄嘌呤的健康益处。
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Sweet taste and menthol increase cough reflex thresholds.甜味和薄荷醇能提高咳嗽反射阈值。
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